Establishment of alternatives to animal testing

The restructured human corneal liberation method (RhCE method) has been newly introduced. This can be used as an alternative method for eye stimulus testing for quasi-drug applications, In Japan, however, the safety evaluation of quasi-drugs with new ingredients necessarily requires results from animal experiments for the hazard evaluation of that particular raw material. At the same time, in other countries, discussions are being actively promoted on the development of evaluation methods without using any animals, the establishment of safety evaluation methods, and the utilisation of animal experiment results carried out for purposes other than cosmetics, but the policy for safety evaluation of final products in Japan remains unchanged.


  • In light of recent significant changes in the concept of safety assessment of final products, Japan should establish risk assessment methods for final products using available scientific evidence in order to prevent unnecessary animal experiments, while promoting the development of alternative methods that do not use animals at all.